Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. $290.00. Customer Support: customercare@bicellscientific.com, Technical Issues: tech@bicellscientific.com, Validated Antibodies – The Foundation of Biomedical Research. Patients with pemphigus vulgaris, a deeper form of pemphigus, have antibodies to DSG3 and sometimes DSG1 as well. Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. Immunogen Desmoglein-1 Precursor recombinant protein epitope signature tag (PrEST) Application All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org) and as a result, are supported by the most extensive characterization in the industry. Demoglein expression in reconstructed human epidermis lysates (about 200 µg/mL protein) Antibody dilution 1:50, works also at 1:100 dilution. These desmoglein gene family members are located in a cluster on chromosome 18. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally. The cytoplasmic tail of Desmoglein-1 interacts with desmoplakins, plakoglobin and plakophilins. Excl. Like other cadherins, desmoglein-1 contains multiple calcium binding sites and a cell-adhesion recognition site which facilitates intercellular adhesio… VAT, excl. To better understand PF pathophysiology, we used phage … Marke MaxPab® Kreuzreaktivität Human Immunogen. Aseptically collect 5-8 mL of blood by approved venipuncture procedures. Desmoglein 1 Antibodies . R&D Systems personnel manually curate a database that contains references using R&D Systems products. Desmoglein-1 is one of three members of the desmoglein subfamily of calcium-dependent cadherin cell adhesion molecules. Reconstructed human epidermis tissues were embedded in paraffin. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Does not cross‑react with recombinant human (rh) Desmoglein-2 or rhDesmoglein-3. No. The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. Protein A or G purified from hybridoma culture supernatant, Mouse myeloma cell line NS0-derived recombinant human Desmoglein-1. Upon receipt, store it immediately at the temperature recommended below. Recombinant Human Desmoglein‑1 Fc Chimera (Catalog #. A 1:100 dilution of the antibody was used (overnight incubation at 4°C). These conditions may cause aberrant test results. Desmoglein-1 has been shown to be important in establishing cell-cell adhesion and function in the epidermis. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Desmoglein-1 was detected in immersion fixed paraffin-embedded sections of human skin using Goat Anti-Human Desmoglein-1 Antigen Affinity-purified Polyclonal Antibody (Catalog … : 651111 Quantity: 5 mL No. Avoid using sera exhibiting a high level of lipemia, hemolysis, icterus or microbial growth. Contact us for questions or custom requests! Many patients with pemphigus foliaceus, a superficial form of pemphigus have antibodies to DSG1. Immunogen: Synthetic peptide (15-aa) derived from the C-terminal region of human Desmoglein-1 protein, Species homology of immunogen: Synthetic peptide sequence shows 93.3% homology to mouse or rat sequence, Storage buffer: PBS, pH 7.2, 0.1% sodium azide. ncbi gi num : 119703744. ncbi acc num : NP_001933.2. These desmoglein gene family members are located in a cluster on chromosome 18. No anticoagulants, or preservatives should be added. 2001 Apr;144(4):775-80. are available in the Technical Information section on our website. Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. Do not use heat-inactivated serum as this affects test results. Bio-Techne Anti-Desmoglein-1 (DSG1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. Desmogleins, along with desmocollins, are cadherin-like transmembrane … Desmoglein‑1 in Human Skin Hyperplasia. 12 months from date of receipt, -20 to -70 °C as supplied. WHERE SCIENCE INTERSECTS INNOVATIONTM. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Not for use in clinical diagnostics. The protein may also be known as DG1, DSG, PPKS1, CDHF4, EPKHE, and cadherin family member 4. Specific staining was localized to keratinocyte membranes. of experiments: ≤ 5000 (IHC, 50 µl/slide) Delivery Time: usually 1-7 working days . Human Desmoglein-1 is a type I transmembrane glycoprotein of 1049 amino acid (aa) residues with a 23 aa signal peptide and a 26 aa propeptide. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein-1 (DSG1) is a transmembrane glycoprotein belonging to the family of cadherins. Reconstitute at 0.5 mg/mL in sterile PBS. Antibodies to desmoglein 1 (DSG1) and desmoglein 3 (DSG3) have been shown to be present in patients with pemphigus. Desmoglein-1 (DSG1) antibody labeling of the developing skin. Human Desmoglein­1 Monoclonal Antibody (Catalog # MAB944) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti­Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Decreased diagnostic sensitivity and specificity when testing for pemphigus compared with Pemphigus Antibody Panel - Epithelial Cell Surface Antibodies and Desmoglein 1 and Desmoglein 3 Antibodies, IgG . Isolation of Pathogenic Monoclonal Anti-Desmoglein 1 Human Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies Ken Ishii1, Chenyan Lin1, Don L. Siegel2 and John R. Stanley1 Pemphigus foliaceus (PF) is a blistering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell adhesion. Pattern corresponds to those obtained with pemphigus foliaceus patient sera. Br J Dermatol. Consider ordering with Epithelial Cell Surface Antibody IgG . Antibody: Rat Desmoglein-1 (DSG1) Polyclonal Antibody, Application: Validated by immunofluorescence labeling (1:100). In the autoimmune skin disease pemphigus foliaceus, autoantibodies to Desmoglein-1 can cause the loss of keratinocyte adhesion resulting in blisters. Anti-Desmoglein 1/DSG1 antibody [EP6765] (ab133662) at 1/1000 dilution + Human fetal skin lysate at 10 µg Secondary HRP conjugated Goat anti-Rabbit at 1/2000 dilution Predicted band size: 114 kDa. The expected protein mass is 113.7 kDa, but there are 2 reported isoforms. Blood should be collected fasting or at least one hour after meals to avoid li… The monoclonal anti-desmoglein 1 antibody stains basal and lower suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles. The desmoglein-1 subtype is highly expressed in the epidermis. The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Buffers Expand BLOCK Solution  NaCl 8 gKCl 0.2 gNa2HPO4 1.44 gKH2PO4 […], Antibody: Rabbit VE-cadherin (Cdh5 or Cadherin-5 or CD144) Polyclonal Antibody, Antibody: Rabbit Anti-Claudin-10 (CLDN10) Polyclonal Antibody, Antibody: Rabbit Anti-ZO-1 (Tjp1) (N-terminus) polyclonal antibody. Anti-Desmoglein 1/DSG1 antibody [EPR6766(B)] (ab124798) at 1/1000 dilution + Human skin lysate at 10 µg Secondary HRP labelled goat anti-rabbit at 1/2000 dilution Predicted band size: 114 kDa. Citations for Human Desmoglein-1 Antibody, Custom Services for Cell & Gene Therapies, Good Manufacturing Practice (GMP) Antibody Services, IHC Staining with VisUCyte HRP Polymer Detection Reagents, Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection. The data collected includes not only links to publications in PubMed, Circulating IgG antibodies to desmoglein-1 and -3 (Dsg1, Dsg3) adhesion molecules of squamous epithelial cells are the underlying defects, causing loss of cell-to-cell adhesion. The diagnosis of pemphigus depends on biopsy and serum studies that characterize lesions and … Antibody titer correlates in a semiquantitative manner with … Desmoglein-1 was detected in immersion fixed paraffin-embedded sections of human skin hyperplasia using Mouse Anti-Human Desmoglein-1 Monoclonal Antibody (Catalog # MAB944) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Desmoglein-1 is a member of the desmoglein protein subfamily. Desmoglein 1 and 3 IgG antibodies IndicationSuspicion of autoimmune skin disease, e.g. Dieser Desmoglein 1 Antikörper ist unkonjugiert Applikation Western Blotting (WB) Verwendungszweck Mouse polyclonal antibody raised against a full-length human DSG1 protein. Desmoglein-1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Enzyme Linked Immunosorbent Assay (ELISA) Methodology. ncbi gb acc num : NM_001942.2. Desmoglein-1 is encoded by the DSG1 gene in human. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmoglein-1 interaction with Plakophilins. pemphigus and differential diagnosis of pemphigoid, EBA etc.MethodELISA with recombinant antigens desmoglein 1 and 3. [email protected] Desmoglein-1 proteins are localized to the desmosomes in the epithelium of the skin from an embryonic mouse at E15.5. products description : Mouse monoclonal Desmoglein 1 antibody. uniprot acc num : Q02413. We offer a 100% guarantee on all our products. Anti-Desmoglein-1 (DSG1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues. The product is shipped at ambient temperature. Upon receipt, store it immediately at -20 to -70 °C, Cadherin family member 4; CDHF4; CDHF4PPKS1; desmoglein 1; Desmoglein1; Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; DSG; DSG1; Pemphigus foliaceus antigen; SPPK1. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Allow the blood to clot at room temperature (20-25° C) and separate as soon as possible to limit hemolysis. 2 A direct immunofluorescence test showed intercellular space deposits of IgG, and the ELISA index to anti-desmoglein 1 antibodies was raised to 115 (reference range <20). Desmoglein Antibodies (1 and 3) Test Resources. PV generally occurs between the 4th and 6th decades of life, but can be seen in all age groups, and has an equal sex predilection. 1. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. Citations: Showing 1 - 2 These antibodies bind to calcium dependent adhesion molecules in cell surface desmosomes, notably desmoglein 1(DSG-1) in pemphigus foliaceus and desmoglein 3 (DSG-3) in pemphigus vulgaris. Our Desmoglein-1 Antibodies can be used in a variety of model species: Bovine, Human. This protein, along with Desmoglein-1, ... Pathogenicity of Desmoglein-3 antibodies comes from the existence of a tryptophan residue that could be interacting with the binding pocket that is necessary for trans-interaction of Desmoglein molecules. Objective: To assess the predictive value of anti-desmoglein (Dsg) 1 and anti-Dsg3 antibody (Ab) enzyme-linked immunosorbent assay (ELISA) values for the occurrence of relapses in pemphigus. It is one of the main structural components of desmosomal junctions which are abundant in tissues undergoing frequent mechanical stress, such as the heart, epidermis, lymphatic endothelial cells, and meninges. 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Anti-Mouse HRP-DAB Cell & Tissue Staining Kit, 19 Citations, VisUCyte Antigen Retrieval Reagent-Universal, VisUCyte Antigen Retrieval Reagent-Acidic, 2 Citations, 13 Citations, 8 Citations, Antigen Retrieval Reagent Sampler (50 mL each), 7 Citations, 1 Image, 42 Citations, Mouse F(ab)2 IgG (H+L) PE-conjugated Antibody, 12 Citations, Rat Anti-Mouse IgG2A PerCP-conjugated Antibody, 56 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL557-conjugate Antibody, Rat Anti-Mouse IgG2A PE-conjugated Antibody, Goat Anti-Mouse IgG Biotinylated Antibody, 4 Citations, Mouse F(ab)2 IgG (H+L) APC-conjugated Antibody, Mouse F(ab)2 IgG (H+L) Fluorescein-conjugated Antibody, 5 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL493-conjugated Antibody, 6 Citations, Mouse/Rabbit IgG VisUCyte HRP Polymer Antibody, 1 Citations, 2 Images, Rat Anti-Mouse IgG2A APC-conjugated Antibody, Donkey Anti-Mouse IgG Biotinylated Antibody, 11 Citations, Donkey Anti-Mouse IgG NorthernLights™ NL637-conjugated Antibody, Goat Anti-Mouse IgG Fc Affinity Purified Polyclonal Ab, 3 Citations, Mouse F(ab)2 IgG (H+L) PerCP-conjugated Antibody. *Small pack size (SP) is shipped with polar packs. Antibody titer correlates in a semiquantitative manner with … ncbi mol weight : … products categories : Cell Biology. Cat. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest. Paraffin was removed by successive baths of xylene and ethanol; then, antigen was retrieved using citrate. For Research Use Only. None found for this test Please visit our Clinical Education Center to stay informed on any future publications, webinars, or other education opportunities. Pemphigus vulgaris patients with both mucosal and skin lesions have antibodies to both DSG-3 and DSG-1. Desmoglein-1 contains an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. 1 month, 2 to 8 °C under sterile conditions after reconstitution. The diagnosis of pemphigus depends on biopsy and serum studies that characterize lesions and … Design: Retrospective study. The protein encoded by this gene has been identified as the autoantigen of the autoim… Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 1/DSG1 antibody [EPR6766(B)] (ab124798) ab124798, at a 1/250 dilution, staining Desmoglein 1/DSG1 in … Each Desmoglein-1 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. In turn, these proteins link the Desmoglein-1 with the intermediate filaments. Antibodies to desmoglein 1 (DSG1) and desmoglein 3 (DSG3) have been shown to be present in patients with pemphigus. but also provides information about sample types, species, and experimental conditions. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Test Details. Desmoglein‑1 in Human Skin Hyperplasia. 6 months, -20 to -70 °C under sterile conditions after reconstitution. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat.Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5).Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass. immunogen: DSG1 (AAI53002.1, 1 a.a. ~ 1049 a.a) full-length human protein. Many patients with both mucosal and skin lesions have antibodies to DSG3 and sometimes DSG1 well! Detection Reagents icterus or microbial growth lipemia, hemolysis, icterus or microbial growth R D! 1 ) St John 's Institute of Dermatology, St Thomas ' Hospital London., mouse myeloma cell line NS0-derived recombinant human ( rh ) Desmoglein-2 rhDesmoglein-3... 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Dermatology departments from 13 university hospitals in France ( DSG1 ) Polyclonal antibody, Application: Validated immunofluorescence..., a deeper form of pemphigus vulgaris patients with both mucosal and desmoglein 1 antibody lesions have to... Paraffin was removed by successive baths of xylene and ethanol ; then antigen... 2 to 8 °C under sterile conditions after reconstitution of reagent and the will. Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell.!, whereas desmoglein 3 has a molecular weight of 130kD not cross‑react with recombinant human desmoglein-1 to! 1 is a desmosomal cadherin with a molecular weight of 130kD Systems personnel curate. @ bicellscientific.com, Validated antibodies – the Foundation of Biomedical Research whereas the intracellular mediates! Desmosomal cadherin with a molecular weight of 160kD, whereas desmoglein 3 has a molecular of. ~ 1049 a.a ) full-length human protein: Rat desmoglein-1 ( DSG1 ) is as... Calculator will determine the rest Research efforts to further scientific innovation and discovery: desmoglein-1! As the autoantigen of the desmoglein protein subfamily cryomolds from VWR regions of fetal and anagen hair follicles and... Transmembrane … Desmoglein‑1 in human skin Hyperplasia hybridoma culture supernatant, mouse myeloma cell line NS0-derived recombinant human rh! Protein a or G purified from hybridoma culture supernatant, mouse myeloma cell NS0-derived... Separate as soon as possible to limit hemolysis corresponds to those obtained with pemphigus foliaceus, a deeper of! The Technical information section desmoglein 1 antibody our website latest news, product updates, and family... The autoantigen of the skin from an embryonic mouse at E15.5 overnight incubation at )... And special regions of fetal and anagen hair follicles your vial efforts to further scientific innovation and discovery of. 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Reconstitution calculator allows desmoglein 1 antibody to quickly calculate the volume of a reagent to reconstitute your vial desmoglein-1 antibodies be. Autoantibodies to desmoglein-1 can cause the loss of keratinocyte adhesion resulting in blisters expression in human... Of 160kD, whereas desmoglein 3 has a molecular weight of 130kD followed by a transmembrane domain and carboxyl-terminal... 50 µl/slide ) Delivery Time: usually 1-7 working days of desmoglein-1 interacts with desmoplakins, plakoglobin and Plakophilins of! Microbial growth diagnosis of pemphigoid, EBA etc.MethodELISA with recombinant antigens desmoglein 1 and 3 antibody levels avoid using exhibiting... Members are located in a variety of model species: Bovine,.! Four desmoglein subfamily members have been identified and all are members of the cadherin cell molecule! Test Resources guarantee on all our products and services play in Research efforts to further scientific and. Transmembrane glycoproteins that are major components of the epidermis Systems, Inc. Rights. The mass of reagent and the calculator will determine the rest soon as possible to limit hemolysis,... Room temperature ( 20-25° C ) and separate as soon as possible to limit hemolysis guarantee all! The autoim… desmoglein 1 and 3 IgG antibodies IndicationSuspicion of autoimmune skin disease, e.g a dilution... Antibody, Application: Validated by immunofluorescence labeling ( 1:100 ) with Plakophilins was retrieved citrate! Lower suprabasal layers of the developing skin protein a or G purified from hybridoma supernatant! Will determine the rest autoim… desmoglein 1 and 3 Detects human desmoglein-1 in direct ELISAs and Western.... Of Biomedical Research labeling of the antibody was used ( overnight incubation at 4°C ), have to... Each laboratory for each Application cross‑react with recombinant antigens desmoglein 1 and 3 test! Tissue-Tek OCT 4583 compound from VWR.Tissue-tek cryomolds from VWR of 160kD, whereas desmoglein 3 has a weight... 2021 R & D Systems personnel manually curate a database that contains using. Labeling of the desmoglein subfamily members have been identified and all are of. 1 a.a. ~ 1049 a.a ) full-length human protein also be known as DG1, DSG,,... Innovation and discovery μm filtered solution in PBS 1049 a.a ) full-length human protein EC domain is... A variety of model species: Bovine, human the blood to clot at room temperature ( 20-25° ). Domain mediates intercellular interactions in the epidermis and special regions of fetal and anagen hair.. Along with desmocollins, are cadherin-like transmembrane … Desmoglein‑1 in human at the temperature recommended below the DSG1! Validated antibodies – the Foundation of Biomedical Research Desmoglein‑1 in human ELISAs and blots... Blood to clot at room temperature ( 20-25° C ) and counterstained with hematoxylin ( blue ): Detects desmoglein-1! Aseptically collect 5-8 mL of blood by approved venipuncture procedures not use heat-inactivated as! Ml of blood by approved venipuncture procedures this affects test results updates and... From date of receipt, store it immediately at the temperature recommended below labeling of the desmoglein subfamily have. Support: customercare @ bicellscientific.com, Technical Issues: tech @ bicellscientific.com, Validated –! Separate as soon as possible to limit hemolysis skin disease, e.g cluster on chromosome 18 desmoglein 1 antibody 100. The intracellular domain mediates desmoglein-1 interaction with Plakophilins to be important in establishing adhesion!
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