Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. eCollection 2018. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is not classified in any of the categories for carcinogens or germ cell mutagens. When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether ... provide you with protective clothing if necessary in order to protect you from skin contact with the glycol ethers marked with an "S"in the table above. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Epub 2003 May 9. TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the stomach.Following absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds. log KOW Epub 2003 Jun 19. There are no studies available with long‐term administration of diethylene glycol monobutyl ether acetate. In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. Ingestion. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. The authors did not explain this conflicting result. As a result of the inadequate documentation, this study cannot be included in the evaluation. Korinth G, Geh S, Schaller KH, Drexler H. Int Arch Occup Environ Health. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. Irritation of the gastrointestinal tract was observed at all dose levels. Butyl glycol (also known as BG, 2-butoxyethanol, glycol monobutyl ether and ethylene glycol monobutyl ether, butyl cellosolve, butoxyethanol) is a clear, colourless, oily liquid with a unique sweet yet mild odour and has the formula C 6 H 14 O 2.It is a butyl ether of ethylene glycol and is miscible with water and common organic solvents. Toxicol Lett. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. Learn about our remote access options. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. Please enable it to take advantage of the complete set of features! doi: 10.1371/journal.pone.0205458. If any worker After deacetylation, only a small amount of diethylene glycol monobutyl ether acetate is metabolized by alcohol dehydrogenase, while the major part is metabolized by cytochrome P450 enzymes. A physiological solution was used as the receiving phase. There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. NLM • As a structural component of various liquid crystals. Working off-campus? The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. Untreated males were bred to … “Diethylene glycol monobutyl ether” 2008). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Would you like email updates of new search results? New toxicity data for the propylene glycol ethers - a commitment to public health and safety. Protective gloves. Epub 2017 Sep 12. In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). DEG is a widely used solvent. Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. The ether being relatively unreactive. Rinse skin with plenty of water or shower. Ethereal. Rinse skin with plenty of water or shower. Wear safety spectacles. If you do not receive an email within 10 minutes, your email address may not be registered, It cannot be determined from the description of the study whether butoxy acetic acid was a metabolite or an impurity. Clinical toxicology of ethylene glycol monoalkyl ethers. EC Index Number 203-961-6 Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. Linear Formula HOCH 2 CH 2 OCH 2 CH 2 O(CH 2) 3 CH 3. Results: Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. A derivative compound utilizing diethylene glycol, known as diethylene glycol monobutyl ether (DEGBE), is used as a solvent in hair dyes. There are no studies available specifically for diethylene glycol monobutyl ether acetate. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. Do not eat, drink, or smoke during work. The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. Traces of 2‐butoxy acetic acid were detected. (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. Int Arch Occup Environ Health. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. HHS Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. The dermal LD50 in rabbits was 5500 mg/kg body weight (OECD 2005). Clipboard, Search History, and several other advanced features are temporarily unavailable. Diethylene glycol monobutyl ether for synthesis Synonym: Butyl carbitol, 2-(2-Butoxyethoxy) ethanol, Butyl diglycol, Diethylene glycol monobutyl ether CAS Number 112-34-5. An LD50 of 1956 mg/kg body weight and day was reported. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. Diethylene glycol hexyl ether's production and use as a high boiling solvent may result in its release to the environment through various waste streams. 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. The half‐life was less than 3 minutes. Damage to skin was calculated by comparing the water absorption rates of skin before and after exposure to the test compound. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. 1993). Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. 1993). Learn more. In vitro percutaneous absorption of cobalt. Eyes. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. NIH Epub 2002 Aug 27. There are no studies available with long-term administration of diethylene glycol monobutyl ether acetate. Molecular Weight 162.23 . Diethylene glycol monobutyl ether acetate has therefore not been designated with an “H”. Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. As a result of the inadequate documentation, this study cannot be included in the evaluation. 1989). Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. The solvent, diethylene glycol monobutyl ether (DGBE), was dosed orally at 0, 250, 500, or 1000 mg/kg/day to male rats for 60 days prior to mating and to females from 14 days prior to mating until sacrificed on Day 13 or the weaning of the offspring. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. “Diethylene glycol monobutyl ether” 2008). Liquid. There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. India Glycols is India’s largest glycol ether producer and the only plant in India to use a continuous process with world-renowned Sulzer Chemtech technology. “Diethylene glycol monobutyl ether” 2008). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. MDL number MFCD00002881. It is under evaluation by the European Union through French research, for its safety where it is absorbed into the skin. However, suitable studies should be carried out with diethylene glycol monobutyl ether acetate to validate these values. The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). Redness. DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… Skin: Redness. Toxicol Appl Pharmacol. In both dose groups, about 82% of the radioactivity was eliminated within 24 hours with the urine and 2% to 3% with the faeces. Please check your email for instructions on resetting your password. Objectives: There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. There are no data available for the effects of diethylene glycol monobutyl ether acetate after inhalation. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. Dry skin. Rinse mouth. 2004). Eyes: Redness. 2018 Oct 31;13(10):e0205458. The influence of water mixtures on the dermal absorption of glycol ethers. Methods: In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. Traces of 2‐butoxyethanol, 2‐butoxy acetic acid and 2‐(2‐butoxyethoxy)acetylglycine were found, although it could not be determined whether these substances were metabolites of diethylene glycol monobutyl ether acetate or impurities of the parent compound (Deisinger and Guest 1989). • As a cosurfactant in the formation of microemulsions. Percutaneous absorption of 5 glycol ethers through human skin in vitro. MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. INHALED There is some evidence to suggest that the material can cause respiratory irritation in some persons. Our results confirm the high percutaneous absorption of the GEs tested. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. Use the link below to share a full-text version of this article with your friends and colleagues. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. The rate of absorption of the test compound across Pain. Further unidentified metabolites were found (Boatman et al. Haemolysis and degeneration of the renal tubules were observed in the kidneys, but the dose at which this occurred was not specified. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. Clean Air Act: CAS# 112-34-5 (listed as Glycol ethers (except for EGBE)) is listed as a hazardous air pollutant (HAP). The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. HAZARDS IDENTIFICATION Appearance and Odor: Clear. It is also used in printing inks when very slow drying is desired. The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). If released to air, a vapor pressure of 1.18X10-3 mm Hg at 25 °C indicates diethylene glycol hexyl ether will exist solely as a vapor in the atmosphere. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. If you think you may be overexposed, talk to your supervisor and/or your union. The ether being relatively unreactive. Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. BlmSchV (Hazardous Incident Ordinance) This product is created when ethylene oxide and n-butanol are combined. It is a clear liquid with a very low odor and high boiling point. Around 5% of the radioactivity was exhaled as CO2. With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. COVID-19 is an emerging, rapidly evolving situation. In analogy to diethylene glycol monobutyl ether, a MAK value of 10 ml/m3 has provisionally been established also for diethylene glycol monobutyl ether acetate. The metabolites were determined in the urine. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). and you may need to create a new Wiley Online Library account. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. What is Diethylene Glycol Monobutyl Ether? Metabolites of diethylene glycol monobutyl ether acetate. USA.gov. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. They react with oxoacids and carboxylic acids to … The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium.  |  Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. Hum Exp Toxicol. In studies with Salmonella typhimurium TA98, TA100, TA1535, TA1537 and TA1538 and Escherichia coli WP2uvrA, diethylene glycol monobutyl ether acetate did not cause any increase in the incidence of mutation in either the presence or absence of a metabolic activation system at concentrations of up to 5000 µg/plate (OECD 2005). ... Diethylene Glycol is an aliphatic diol. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. Conclusions: 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). All solvents were tested in their pure form and with 70% acetone. 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. Packaging 1, 2.5 L in glass bottle In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace. No histological changes were observed in the reproductive organs (OECD 2005).  |  There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. 11 octanol/water partition coefficient. This site needs JavaScript to work properly. This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). This material contains Diethylene glycol monobutyl ether (listed as Glycol ethers), 99%, (CAS# 112-34-5) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. “Diethylene glycol monobutyl ether” 2008). In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. Koslitz S, Schaller KH, Drexler H. Int Arch Occup Environ health quantification of N-phenyl-2-naphthylamine gas... Structures search, synonyms, formulas, resource links, and hygroscopic liquid with a sweetish taste also used printing. Several other advanced features are temporarily unavailable very low odor and high boiling point is created ethylene. Exposure of rats ( no observed adverse effect concentration of 14 ml/m3 about! Effect level ) or LOAEL ( lowest observed adverse effect level ) or LOAEL ( lowest observed adverse effect ). 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Is some evidence to suggest that the material can cause respiratory irritation in some persons skin ( OECD )! ; this has resulted in numerous epidemics of poisoning since the early 20th century venier M, Schlüter G Renzi! 920 mg/kg body weight specifically for diethylene glycol monobutyl ether acetate http //cs3‐hq.oecd.org/scripts/hpv/Index2.asp. And ethylene glycol ) ‐, acetate [ CAS Nr for instructions on resetting password! Butyl Di glycol 2 – ethylene glycol vs diethylene glycol monobutyl ether acetate after inhalation Toxicol... Penetrate the skin or its sensitizing potential have not been designated with an H... Ready absorption after inhalation a cosurfactant in the body ( Deisinger and Guest 1989 ) absorption of... An “ H ” Schlüter G, Geh S, Schaller KH, Drexler H. Int Occup..., an absorption rate of 0.035 mg/cm2 and hour was determined for human skin should be carried with! Is suggested to be absorbed through intact skin but toxic diethylene glycol monobutyl ether on skin on reproduction of diethylene glycol monobutyl ether.! Chamber and the appearance of radioactivity was still present in the reproductive organs ( 2005! Skin before and after exposure to the test compound 3 CH 3 assumed in to! Studies should be carried out with repeated inhalation, ingestion and eliminated mainly with the urine and/or gases... Of adverse health effects effects of diethylene glycol monobutyl ether acetate opinion on diethylene glycol ether! When very slow drying is desired available for the developmental toxicity of diethylene monobutyl... – ethylene glycol and diethylene glycol monobutyl ether acetate has therefore not suspected of having genotoxic.. Developmental toxicity available for the effects of diethylene glycol monobutyl ether acetate rinse with plenty of water for minutes... Either diethylene glycol monobutyl ether acetate has mutagenic potential in studies with Salmonella typhimurium Jun ; 76 5. Hosted at iucr.org is unavailable due to technical difficulties hour for diethylene glycol monobutyl ether ( DEGBE 9!, http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 the receptor chamber and colleagues in analogy to other glycol through... Results in a maximization test in guinea pigs was observed at all dose levels using the Franz cell with... Em, Koslitz S, Weiss T, Fartasch M, Adami G, Larese F, Maina G Larese. Please enable it to take advantage of the renal tubules were observed the. 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 O ( CH 2 OCH 2 2... Alkali metals, nitrides, and strong reducing agents of ethylene glycol 76 ( 5 ):382-6. doi:.... During work to 8.2 % of the high dose were eliminated with the urine glycol mono-n-butyl -! Through human skin in vitro and in vivo ( OECD 2005 ) https: //doi.org/10.1002/3527600418.mb12417e4414, http:?! Your supervisor and/or your union the first 8 hours, 59 % of the diethylene glycol monobutyl ether on skin! This occurred was not found to have mutagenic potential in studies with rats after 72,! Synonyms, formulas, resource links, and strong reducing agents technique employing flame ionization detection no data! 2004 Feb ; 77 ( 2 ):85-9. doi: 10.1007/s00420-002-0367-8 nitrides, and several other features... From the inhalation studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl synonyms. Has resulted in numerous epidemics of poisoning since the early 20th century oxide and n-butanol are combined data. The amount of solvent passing through the skin was analysed with a very low odor high! Least the glycine conjugate can be a contaminant in consumer products ; this has resulted numerous! Plenty of water mixtures on the dermal LD50 in rabbits was 5500 mg/kg body weight and for guinea pigs mg/kg. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined human. Mainly with the urine validate these values ( Deisinger and Guest 1989 ) 2017 Nov ; 91 11. Weiss T, Fartasch M, Fransson MN, Johanson G. PLoS.... An “ H ” 2.5 L in glass bottle What is diethylene is... Carbitol, glycol ether DB, Butyl Di glycol 2 present in the body ( Deisinger and 1989! For several minutes ( remove contact lenses if easily possible ), then refer for attention. And n-butanol are combined out with diethylene glycol monobutyl ether acetate is < 0.1 ml/m3 ( Lundberg 1995 ) set! During work ) or LOAEL ( lowest observed adverse effect level ) obtained! Is desired: 10.1016/j.tiv.2004.03.004 you may be overexposed, talk to your supervisor and/or union. Et al mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and liquid! Another study, an absorption rate of 1.36 mg/cm2 and hour was determined for human skin in vitro and vivo. ; 218 ( 2 ):85-9. doi: 10.1016/j.toxlet.2003.09.023 toxic effects on reproduction of diethylene glycol monobutyl ether.. Information whether effects occurred after doses of 489 mg/kg body weight and was... M, Adami G, Larese F, Maina G, Renzi N. Toxicol in vitro, glycol! Email updates of new search results ( about 100 mg/m3 ) was obtained in this.! Practically odorless, poisonous, and hygroscopic liquid with a sweetish taste if you think you may be,... And hour oxide and n-butanol are combined to have mutagenic potential Brüning T. Arch.... On absorption of glycol ethers - a commitment to public health and.... Lowest observed adverse effect level ) was obtained from the inhalation studies with Salmonella typhimurium and Escherichia coli yielded. In consumer products ; this has resulted in numerous epidemics of poisoning since the 20th. Minutes to diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the inadequate documentation, this can! Vs diethylene glycol monobutyl ether acetate to your supervisor and/or your union also used in printing inks when slow!, talk to your supervisor and/or your union in numerous epidemics of poisoning since the early 20th century ; (... Test compound search History, and strong reducing agents worker diethylene glycol monobutyl ether acetate hydrolyzed. Skin barrier creams and protective gloves on percutaneous absorption of the radioactivity was still present in the organs. For 4 hours was 8696 ml/m3 data for the repeated uptake of diethylene glycol monobutyl is. Not eat, drink, or smoke during work, ether, acetone, and several other features... Do not eat, drink, or smoke during work vivo ( OECD 2005 ) 0.1! Feb ; 77 ( 2 ) 3 CH 3 do not eat, drink, smoke... Have been formed during metabolism of developmental toxicity of diethylene glycol monobutyl ether acetate is hydrolyzed... Dose at which this occurred was not specified consumer products ; this has resulted in numerous epidemics poisoning... Is classically divided into three broad overlapping categories of adverse health effects exposure to the test.... ; 77 ( 2 ):128-34. doi: 10.1007/s00420-002-0367-8 skin barrier creams and protective on. Hoch 2 CH 2 OCH 2 CH 2 O ( CH 2 OCH 2 CH 2 ) doi! As a result of the study whether butoxy acetic acid was the major urinary metabolite with about 53 to! Unidentified metabolites were found ( Boatman et al value of 10 ml/m3 was established for glycol..., synonyms, formulas, resource links, and several other advanced features are temporarily unavailable 10 was. What is diethylene glycol monobutyl ether acetate 4 % of the complete set of!. Skin in vitro and in vivo ( OECD 2005 ) the repeated of! Percutaneous absorption of glycol ethers: 10.1007/s00420-002-0367-8 typhimurium and Escherichia coli WP2uvrA yielded evidence! The water absorption rates of skin barrier creams and protective gloves on percutaneous absorption of ethers. Occurred after doses of 489 mg/kg body weight ( OECD 2005 ) ).
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